Calcitriol (the active form of vitamin D) binds to VDR, which then forms a heterodimer with the retinoid-X receptor.The VDR heterodimer then enters the nucleus and binds to VDR responsive elements in genomic DNA.VDR binding results in expression or transrepression of specific gene products. 2 comments. A number of genetic polymorphisms have been shown to predispose certain individuals to depression. Bsm I polymorphism [13-18]. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the insulin resistance syndrome. As there was a strong positive LD between Taq-I and Bsm-I SNPs, indicating two alleles occurred on the same haplotype more than expected. In addition, Bsm-I and ApaI SNPs were also in LD with each other (R2 = −0.61) (Supplementary Table S1). We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an … We want to keep Genetic Genie free. on the VDR TaqI polymorphism, 8 on the VDR BsmI polymorphism, and 5 on the VDR ApaI polymorphism. Wow, I have all of those mutations as well including VDR Taq ++. save. That's only half the destination! hide. So if there is a (+/+) VDR Tak, there would be a (-/-) VDR Bsm. Of particular interest are the polymorphisms of the vitamin D receptor (VDR) gene. In conclusion, VDR BsmI variant was associated with hypertriglyceridemia and may be predisposed to developing MetS. PDF | Objective Prostate cancer is a malignant tumour that poses a serious risk to human health. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age and sex-matched healthy individuals. The relation between FokI (ff) genotype polymorphism and increased level of serum 1,25(OH)D3 in … In contrast, after stratification If someone is VDR BSM +/+ they will be VDR Taq -/-. Much research has been focused on various genotypes associated to the VDR, vitamin D binding protein (DBP) and vitamin D-1-α-hydroxylase. L-Tyrosine seems to hit and miss for me, does not work most of the time. Of the 59 MTHFR SNPs that 23andme has in the raw data I found 13 with peer reviewed research. Most studies on VDR polymorphisms include FokI (T/C) (rs2228570), ApaI (C/A) (rs7975232), TaqI (T/C) (rs731236) and BsmI (A/G) (rs1544410) (Slattery et al., 2001; Denzer et al., 2011). What do you make of this article about watching the intake of Vit D. and monitoring the levels of 25OH and 1.25OH? The particular SUOX that Dr Yasko tests for is not in 23andme’s raw data. These are the two vitamin D receptor polymorphisms which Genetic Genie will report on if you upload your DNA analysis from 23andme to them. Hi everyone. VDR Vitamin D Receptor “Determines donors” VDR Taq tt = -/- (green, no defect) tolerates fewer methyl donors VDR Taq TT = +/+ (red, complete defect) tolerates more methyl donors Partial or complete defects may mean you will not readily absorb Vit D from sun exposure. Marcia McPhail: Vit D mobilizes calcium through the intestines to the bloodstream. The PCR and restriction enzymes BsmI, ApaI, and TaqI were used to identify the polymorphic alleles B/b, A/a, and T/t, as previously described (4, 8, 9, 11). Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) are commonly studied in several pathologies. +/+ MTHFR A1298C, VDR Taq, BHMT-08, CBS A360A +/-COMT V158M, COMT H62H, MTRR A66G, BHMT-02, BHMT-04, AHCY-01, AHCY-02, AHCY-19; I decided to put this blog post together to summarize how each of these things specifically affects my body. A total of 65 (14929 samples), 31 (7697 samples), 18 (3617 samples), and 26 (5353 samples) studies for Bsm I, Apa I, Fok I, and Taq I polymorphisms, respectively, were included. Nutrahacker does not report on any Vitamin D receptor polymorphisms. This may also contribute to seasonal depression, particularly when the sun is at it's lowest in the fall/winter season. We found that several VDR variants FokI, BsmI, and TaqI polymorphisms are related to ASD. However more recently they no longer test VDR Bsm, and instead only test VDR Taq. However, this is not always the case. But basically the research shows small effects in either direction. Heritability of major depressive disorder (MDD) is between 36 and 44%, suggesting that up to nearly half of the phenotypic variability is attributable to genes. In con-clusion, the Bsm I polymorphism is regarded as one among VDR gene polymorphisms at Taq-I were in LD with both Bsm-I and Apa-I (R2 = 0.87 and −0.44 respectively). Yasko used to test the 3 VDR SNPs Fok, Bsm and Taq. The VDR polymorphism can play a role in the development of ASD by influencing the action pathway of vitamin D . Posted by 21 hours ago. It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. VDR Taq I and Bsm I polymorphisms seems to influence serum 25(OH)D levels in MetS subjects, while Cdx2 polymorphism may influence WC in all subjects. I am homozygous for the VDR Taq gene. In this study, we performed a case-control study to clarify the association of four VDR gene polymorphisms BsmI, TaqI, ApaI and FokI with deciduous tooth decay in Chinese children. report. COMT +/- and VDR Taq +/+ or do best with Hydroxy or Adnosyl & less Methyl COMT +/- and VDR Taq +/-do best with Hydroxy or Adenosyl COMT +/+ and VDR Taq +/- or +/+ do best with Hydroxy or Adenosyl COMT +/+ and VDR Taq -/-will do best with mostly Hydroxy For a more detailed list check out Dr. Yasko's Simplified Roadmap. VDR Taq rs731236 VDR Bsm rs1544410. I've been supplementing 5000 UI Vit D3 for some months but honestly don't know about the difference. The vitamin D receptor (VDR) encoded for by the gene VDR is the receptor for the bioactive form of vitamin D, calcitriol. Previous work investigated potential risks between Taq I (rs731236) and Bsm I (rs1544410) VDR polymorphisms with prostate cancer in humans; however, results are inconsistent. I’m going to tackle the homozygous SNPs first, the ones where I have two copies of the “bad” SNP. It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M + and a VDR Taq + status. The reason for this is because they claim that VDR Bsm and Taq "track" each other for the vast majority of people, i.e. As VDR polymorphisms have no known functional significance, these findings may implicate a variant of the VDR gene or a locus in linkage disequilibrium with the VDR. Meta-analysis of the VDR FokI polymorphism showed no association between PTB and the f allele of the VDR FokI polymorphism (long variant) in all subjects (OR = 1.070, 95%CI = 0.979-1.169, P = 0.134). Epidemiological studies suggest that it may be associated with vitamin D receptor gene (VDR) polymorphisms.... Association of VDR polymorphisms (Taq I and Bsm I) with prostate cancer: a new meta-analysis - Sheng Liu, Hairong Cai, Weisong Cheng, … VDR Tak and VDR Bsm are usually inverse from eachother. Even paternal VDR polymorphism can be a causative factor for ASD in the offspring. Having VDR BSM +/+ is the one associated with low D3 levels. The frequency of VDR polymorphisms in Bsm-I among HIV-infected patients in West Java were considered high for b allele (88.6%), and in contrast for A allele in Apa-I that was 73.91%. The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. a mutation in one SNP corresponds to … In the present meta-analysis, four common VDR gene polymorphisms (BsmI, ApaI, FokI, and TaqI) were included. HI Dr. K, I have a VDR receptor defect. a mutation in one SNP corresponds to a mutation in another. However, this is not always the case. There are other Vitamin D receptors and other polymorphisms. VDR Bsm -/- and VDR Taq +/+ are basically the same thing. The reason for this is because they claim that VDR Bsm and Taq "track" each other for the vast majority of people, i.e. 2. Polymorphisms of the vitamin D receptor (VDR) gene have been linked to both multiple sclerosis (MS) and osteoporosis. Yasko did or still does report the contradictory versions as being the "risky" version, even though it makes no sense at all. VDR gene polymorphisms Bsm I, Taq I, and Apa I, located at the VDR 3´ untranslated region, were associated with low bone mineral density and osteoporosis [6, 19]. Help keep us free! Several polymorphisms of the VDR gene have been identified, including 2 restriction fragment length polymorphisms (RFLPs) in intron 8 (Bsm I and Apa I) and one in exon 9 (Taq … Vitamin D plays a key role in the absorption of calcium from the gut, which is required for healthy bone formation, muscle, and heart activity as well as numerous other cell functions. I am VDR Bsm (+/-), VDR Taq(+/-) vitamin D level very low ( 17). Genotyping of Taq-I (rs731236) and Bsm-I (rs1544410) was performed using TaqMan® SNP Genotyping Assay. Methylation Analysis Results Gene & Variation rsID Alleles Result COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CC -/- VDR Taq rs731236 AA +/+ VDR Fok-I not found n/a n/a MAO A R297R rs6323 T + ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 AG +/- […] However more recently they no longer test VDR Bsm, and instead only test VDR Taq. Yasko used to test the 3 VDR SNPs Fok, Bsm and Taq. I removed it because of all of the confusion. Objective Prostate cancer is a malignant tumour that poses a serious risk to human health. But because of declining donations and the economic impacts of COVID-19, it’s possible that this may no longer financially work.We’re doing cool new things (check out GenVue), we are in the process of updating/adding new panels and we added support for Whole Genome Sequencing. The vitamin D receptor (VDR), a nuclear hormone receptor, is essential for vitamin D action and calcium homeostasis. 6 years, 11 months ago. The VDR 5´ polymorphism Fok I seemed to be associated with peak bone mass [20]. Epidemiological studies suggest that it may be associated with vitamin D receptor gene (VDR) polymorphisms. What should be done ? I certainly feel like low dopamine too most of the time. Identified genotypes of Fok-1(rs2228570) are FF, Ff, ff; Bsm-I (rs1544410) are BB, Bb, bb; Taq I (rs731236) genotypes are TT, Tt, tt, and Apa-I (rs79752320 are AA, Aa, and aa). Polymorphisms that have been recognized in VDR gene, specifically Apa I, Taq I, Fok I and Bsm I may be related with T2DM, lack of insulin sensitivity and dysfunction of pancreatic beta cell. VDR BSM (rs1544410) VDR TAQ (rs731236) ACE (rs4343) AGT (rs699) FOLR2 (rs651933) MTHFD1 (rs1076991) NOS3 (rs7830) SOD3 (rs2855262) HLA-DQA2 (rs2858331) IGF1R (rs2229765) TRAF1 (rs3761847) 4. The aim of the present study was to evaluate polymorphisms of fat mass and obesity (FTO; rs9939609) and vitamin D receptor (VDR, FokI (rs2228570), BsmI … Genetic Genie just generates the list based on whatever Yasko says about the SNPs. VDR Tak and VDR Bsm are usually inverse from eachother. share.