Aldosterone antagonists are used for hypertension as well as heart failure after a heart attack. It plays a central role in the homeostatic regulation of blood pressure, plasma sodium (Na +), and potassium (K +) levels. But we can start with reviewing the major trials of ARAs. One of these is the use of stems that are reserved for drugs with particular mechanisms of action, clinical use, chemical structure etc. Learn term:anh = antagonist of aldosterone with free interactive flashcards. 2.Antiarrhythmic classification • Class I agents interfere with the sodium (Na+) channel. • Class IV agents affect calcium channels and the AV node. Drug names used in the NLM Drug Information Portal are structured by committees to reflect the type of condition that the drug is used for. A complete review of all clinical trials evaluating ARA trials in patients with HFpEF can be found in Table 1. • Class II agents are anti-sympathetic nervous system agents. Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart failure are reviewed. The most common medication in this class to be familiar with is eplerenone, which goes by the brand name Inspra. • Class III agents affect potassium (K+) efflux. narcotic antagonists/agonists related to 6,7-benzomorphan ... aldosterone antagonists, spironolactone derivates-restat (or -restat-) see –stat: retin: retinol derivatives ... infix or suffix, within the INN. An antimineralocorticoid, also known as a mineralocorticoid receptor antagonist (MCRA) or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure. Aldosterone receptor antagonists are proven to be beneficial in heart failure patients even if they are already on angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). In the event that the hyphen is absent, the stem may be used in any position within the name. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. Aldosterone Antagonist - eplerenone. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. There are currently two aldosterone antagonists commercially available in the United States, spironolactone and eplerenone. In choosing a generic or official name for a drug the bodies responsible for these decisions follow a number of guidelines. Angiotensin receptor blockers (also called ARBs or angiotensin II inhibitors) are medicines that dilate (widen) blood vessels, and are used in the treatment of conditions such as high blood pressure (hypertension), heart failure, or kidney disease in people with diabetes.. Eplerenone is used in the treatment of hypertension and congestive heart failure. This is true of most official generic names such as those we label as [USAN] for United States Adopted Name. Mode of Action. Concepts • Class V agents work by other or unknown mechanisms. The dose, mechanisms, and indications are discussed in other sections below. Choose from 125 different sets of term:anh = antagonist of aldosterone flashcards on Quizlet. Most agents in this class are beta blockers. This leads to a decrease in blood pressure. A selective aldosterone receptor antagonist. Aldosterone antagonists block the effects of aldosterone. Aldosterone is the main mineralocorticoid hormone steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. Summary: Heart failure is a clinical syndrome characterized by the functional inability of the ventricle to meet the metabolic demands of the body. ARBs work by blocking the action of a natural chemical called angiotensin II.