2010;25(9):603–5. Moreover, acute-onset type 1 diabetics had a higher frequency of B allele, compared with slow-onset type 1 diabetics. Identification of a membrane receptor for 1, 25-dihydroxyvitamin D3 which mediates rapid activation of protein kinase C. J Bone Miner Res. Journal of Basic and Clinical Pharmacy, 2017. Recently, we have proposed the hypothesis that differences in the degree of regeneration of pancreatic islet cells may be associated with the onset pattern of type 1 diabetes, and we examined a polymorphism of the Neuro D/BETA 2 gene (29), which is considered to be associated with regeneration of pancreatic islet cells (30), in type 1 diabetes. Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes mellitus: an updated meta-analysis. The lengths of the restriction fragments were 649 and 176 bp (b allele). AA, ME and SR performed statistical analysis, interpreted data, drafted the manuscript. Regardless of the presence or absence of each HLA type (DR4, DR9, A24, or Bw54), the distribution of genotype frequencies in type 1 diabetic patients was consistent. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Makoui, M.H., et al., Vitamin D receptor gene polymorphism and susceptibility to asthma: meta-analysis based on 17 case-control studies. 2012;495(2):183–8. The VDR gene encodes the nuclear hormone receptor for vitamin D3. Vitamin D acts via its receptor (VDR). Article  et al. Vitamin D3 is also thought to have immunomodulatory effects, and the rs10735810 VDR gene polymorphism is linked with pertussis. Surendar Aravindhan. 2018;8(1):31. El Gendy HI, et al. Diminished 25-OH vitamin D3 levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases. 1, 25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic beta-cell line. Scientific reports. Google Scholar. 2002;20(3):227–32. Tien-Jyun Chang et al. Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes. 1959;22(4):719–48. Vitamin D receptor gene polymorphisms and 25 (OH) vitamin D: lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients. The authors declare that they have no competing interests. 2020. Gynecol Endocrinol. J Diabetes Complicat. We examined the VDR gene Bsm Ι polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. 1999;25(2):150–6. Ofstad AP, Atar D, Gullestad L, Langslet G, Johansen OE. Ma L, et al. Over the last 5 years, a number of large observational studies have suggested an association between the onset of type 2 diabetes and Vitamin D deficiency. Journal of Obstetrics and Gynaecology Research, 2017. CAS  2012;36(1):1–9. The major physiological role of the vitamin D receptor (VDR) is the maintenance of mineral ion homeostasis. Advances in the genetics of youth-onset type 2 diabetes. PubMed Central  Can J Diabetes. Thymoquinone with Metformin Decreases Fasting, Post Prandial Glucose, and HbA1c in Type 2 Diabetic Patients. 2018;18(8):57. This hormone inhibits T-cell activation both in vitro and in vivo and inhibits secretion of cytokines such as IL-1, IL-2, IL-6, IL-12, TNF, and interferon-γ (9–11), which are believed to be involved in the pathogenesis of autoimmune diseases (12). Nearly every tissue and cell type in your body has receptors for vitamin D, thereby increasing the amounts needed for optimal health. CAS  Journal of Diabetology. - 167.71.215.152. Vitamin D is also involved in several processes unrelated to bone and tooth formation. These receptors function as ligand-activated, transcriptional regulatory proteins. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. 2018;22(2):229–35. 43(3): p. 436–446. PubMed  2016;25(3):614. In acute-onset patients, regardless of the existence of islet-associated autoantibody, there was a significant difference in B allele frequency between type 1 diabetics and controls (Tables 33 and 44). Article  The vitamin D receptor (VDR, a.k.a. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure strength of association. Medicina. Angel B, Lera L, Márquez C, Albala C. The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile. BsmI polymorphisms in vitamin D receptor gene are associated with diabetic nephropathy in type 2 diabetes in the Han Chinese population. Alternative screening protocols may miss most cases of gestational diabetes mellitus during the COVID-19 pandemic. DerSimonian, R. and N. Laird, Meta-analysis in clinical trials control Clin trials 7: 177–188. Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a polish population. PubMed Central  Rasheed MA, Kantoush N, Abd el-Ghaffar N, Farouk H, Kamel S, Ibrahim AA, et al. Maia J, Silva A, Carmo R, Mendonça T, Griz L, Moura P, et al. 2004;215(1–2):31–8. contributed equally to this work. PubMed  Vitamin D receptor gene polymorphisms and HLA DRB1* 04 cosegregation in Saudi type 2 diabetes patients. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes. The association between vitamin D receptor gene polymorphisms (TaqI and FokI), type 2 diabetes, and micro−/macrovascular complications in postmenopausal women. VDR gene polymorphism in subgroups of patients with type 1 diabetes. Heart Fail Rev. Endokrynologia Polska. Considering these results, we speculate that the regeneration of pancreatic islet cells and immunoregulatory effects may independently influence the pathophysiology of type 1 diabetes, although accumulation of more data is needed to reach a conclusion. 1991;49(3):668–73. Psychol Methods. https://doi.org/10.1007/s40200-020-00704-z, DOI: https://doi.org/10.1007/s40200-020-00704-z, Over 10 million scientific documents at your fingertips, Not logged in Two hundred three Japanese type 1 diabetic patients [mean onset age, 34.6 ± 16.9 (range, 1–78) yr old; 96 men and 107 women] and 222 unrelated healthy subjects [44.4 ± 13.7 (range, 20–72) yr old, 101 men and 121 women] were recruited for this study. Gene Reports. Zhang H, Wang J, Yi B, Zhao Y, Liu Y, Zhang K, et al. (2021)Cite this article. Correspondence to Yu F, et al. © 2021 Springer Nature Switzerland AG. 2017;12:1673–9. 2018;175:119–24. Google Scholar. Indian J Med Sci, 2009. Article  Asia Pac J Clin Nutr. Medicine, 2016. Soroush N, Radfar M, Hamidi AK, Abdollahi M, Qorbani M, Razi F, et al. Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). 2015;46(7):572–9. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Intestinal vitamin D receptor knockout protects from oxazolone … No longer known as just the “bone vitamin”, vitamin D also protects against cancer, heart disease, Alzheimer’s, and diabetes. Zhong X, du Y, Lei Y, Liu N, Guo Y, Pan T. Effects of vitamin D receptor gene polymorphism and clinical characteristics on risk of diabetic retinopathy in Han Chinese type 2 diabetes patients. Because vitamin D exerts it action at a cellular level through binding to the VDR, which is an intracellular hormone receptor belonging to the steroid hormone receptor superfamily, the VDR gene has become a candidate gene for T1DM. Yoshiko Motohashi, Satoru Yamada, Tatsuo Yanagawa, Taro Maruyama, Ryuji Suzuki, Masaaki Niino, Toshiyuki Fukazawa, Akira Kasuga, Hiroshi Hirose, Koichi Matsubara, Akira Shimada, Takao Saruta, Vitamin D Receptor Gene Polymorphism Affects Onset Pattern of Type 1 Diabetes, The Journal of Clinical Endocrinology & Metabolism, Volume 88, Issue 7, 1 July 2003, Pages 3137–3140, https://doi.org/10.1210/jc.2002-021881. Mutations in this gene are associated with type II vitamin D … Recent studies have clarified the molecular basis of the immunomodulatory activity of 1,25(OH)2 D3 (6), and its specific nuclear receptors are known to be present on monocytes and activated T lymphocytes (7, 8). reported that the frequencies of HLA A24 and Bw54 were different between acute-onset type 1 diabetics and slow-onset diabetics (18). 2019;15:25–9. Autoantibody against ICA 512 did not improve test sensitivity for slowly progressive IDDM in adults. Vitamin D, Its Receptor Gene Polymorphism and Breast Cancer | … 2019. Type-1 diabetes: a chronic autoimmune disease of human, mouse and rat. Bmj. 2016;144(1):46–51. 2016;536(7614):41–7. Hadi SM, Al-Zubaidy R. Genotyping of vitamin D receptor FOKI polymorphism as a predictor for type 2 diabetes mellitus by a tetra primer-ARMS-PCR assay. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. I33554), PCR amplification of the region containing the polymorphism was performed using the forward primer in exon 7 (5′-CAACCAAGACTACAAGTACCGCGTCAGTGA-3′) and the reverse primer in intron 8 (5′-AACCAGCGGGAAGAGGTCAAGGG-3′). Lower vitamin D levels, but not VDR polymorphisms, influence type 2 diabetes mellitus in Brazilian population independently of obesity. Independently reviewed in 5 review(s). Prevention of diabetes recurrence after syngeneic islet transplantation in NOD mice by analogues of 1,25 (OH). Meta-regression analyses indicated that none of the publication year, ethnicity, and genotyping method were the source of heterogenicity in all four polymorphisms. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. PLoS One. Kautzky-Willer A, Harreiter J, Pacini G. Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. 2015;566(2):212–6. This meta-analysis suggested a significant association between VDR gene FokI, and BsmI (heterozygote model) polymorphisms and T2D susceptibility in overall population and ethnic-specific analysis. Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. 1988;60(2–3):109–17. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Association of Vitamin D Receptor Gene Polymorphism in adults with type 2 diabetes in the Kashmir Valley. 2018;138:271–81. Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Moreover, we stratified type 1 diabetics according to their onset pattern and assessed its relationship to the VDR gene polymorphism. Therefore, the susceptible allele of this gene and the significance of this gene in type 1 diabetes are still controversial. The vitamin D receptor (VDR) is a member of the nuclear receptor/steroid hormone receptor superfamily. Glutamic acid decarboxylase 65 (GAD 65) antibodies and insulin auto-antibodies in Japanese patients with non-insulin dependent diabetes mellitus. Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves’ disease. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. PM and MA originated the study, acquired data. Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. GAD-reactive CD4+ cells existed in type 1 diabetes without islet-associated autoantibody. We would like to thanks all researchers who dedicate their life for science. PubMed Central  Gene. Endocr Res. It is a member of superfamily of the nuclear hormone receptors which acts as a ligand activated transcription factor. AL-Darraji, S.Z., H.F. AL-Azzawie, and A.M. AL-Kharsani, Associations between TaqI Polymorphisms in Vitamin D Receptor Gene and Type 2 Diabetes Mellitus in Obese Iraqi Population. 2019;10(1):e12370. Google Scholar. Mahjoubi I, Kallel A, Sbaï MH, Ftouhi B, Ben Halima M, Jemaa Z, et al. PubMed Central  2018;42(3):251–6. Google Scholar. The vitamin D receptor functional variant rs2228570 (C> T) does not associate with type 2 diabetes mellitus. J Bone Miner Res. Fatma and Abdul noted that “The current study did not provide evidence for the association of VDR gene BsmI polymorphism with T2DM in Pakistani population 1.” Norman AW. Lack of association between FokI polymorphism in vitamin D receptor gene (VDR) & type 2 diabetes mellitus in the Tunisian population. Google Scholar. Johnson JA, Grande JP, Roche PC, Kumar R. Immunohistochemical localization of the 1, 25 (OH) 2D3 receptor and calbindin D28k in human and rat pancreas. Moreover, onset age did not affect the distribution of genotype frequencies in type 1 diabetic patients, because there was no significant difference between patients above and below the mean onset age in each subgroup (groups A, B, and C). Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Rabbit polyclonal Vitamin D Receptor antibody. Demonstration of a high affinity receptor for 1, 25-dihydroxyvitamin D3 in rat pancreas. We, therefore, investigated a vitamin D receptor (VDR) gene polymorphism in type 1 diabetes, considering the possibility that this gene may affect the pathophysiology of this disease. PubMed  Bertoccini L, Sentinelli F, Leonetti F, Bailetti D, Capoccia D, Cimini FA, et al. 124(1): p. 57–69. Uitterlinden AG, Fang Y, van Meurs JBJ, Pols HAP, van Leeuwen JPTM. Am J Hum Genet. Vitamin D receptor genetic polymorphism is significantly associated with risk of type 2 diabetes mellitus in Chinese Han population. Vitamin D and its receptor have been suggested to play a role in the pathogenesis of type 1 diabetes mellitus. Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. 2018;23(3):303–23. By assessing the existence of islet-antigen-reactive T cells in the peripheral blood from those patients, it may be possible to evaluate the pathophysiology in relation to the VDR gene polymorphism in a future study. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. After obtaining informed consent from the recruited subjects, we extracted DNA from peripheral blood. Zaccardi F, Webb DR, Yates T, Davies MJ. Diabetes Res Clin Pract. Therefore, we focused on these four HLA types in relation to the VDR gene in this study. Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, Botella J. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? The image on the right is treated with the synthesized peptide. The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Also, in the VDR-Fok I polymorphism, the F allele seemed to predispose to diabetes; and in the VDR-Taq I polymorphism, the T allele seemed to be protective in Romanian type 1 diabetics (26). Google Scholar. Here we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms and susceptibility to T2D. Clin Interv Aging. Wang X, et al. 2002;51(3):356–9. PubMed Central  Among subjects with GG genotype of the Neuro D/BETA 2 gene, which is considered to be unrelated to the acute-onset pattern, acute-onset subjects had a higher frequency of B allele of the VDR gene than did slow-onset subjects, although the difference did not reach statistical significance (data not shown). Article  Moreover, there was no significant difference regarding the prevalence of the HLA types in each subgroup (groups A, B, and C) as well. Thus, the VDR selectively binds the 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] hormone and controls the expression of selected genes in target cells. Genotype was determined from the lengths of fragments, i.e. The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country. Receptors for 1α, 25 (OH) 2D3: past, present, and future. Department of Electronics and Communication Engineering, Al-ameen Engineering College (Autonomous), Erode, Tamil Nadu, 638 104, India, College of Medicine, University of Babylon, Hillah, Iraq, College of Medicine, University of Babylon, Babil, Iraq, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Chennai, India, Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran, Department of Hematology, School of Medicine, Tarbiat Modares University, Tehran, Iran, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, You can also search for this author in Asian J Pharm Clin Res. 2001;144(4):385–9. This study aims to investigate the association of vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms with susceptibility and severity to multidrug-resistant tuberculosis (MDR-TB) in comparison with drug-sensitive tuberculosis (DS-TB) and … International Journal of Molecular Epidemiology and Genetics. Metabolism-Clinical and Experimental. A1alpha, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians. Knowing your vitamin D levels based on blood testing is one of the most important health investments you can make. Jia J, Ding H, Yang K, Mao L, Zhao H, Zhan Y, et al. The heart failure burden of type 2 diabetes mellitus—a review of pathophysiology and interventions. Sex did not affect the distribution of genotype frequencies in each subgroup as well. Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. 1998;47(4):688–90. 2002;51(7):2294–300. Article  In non-obese diabetic (NOD) mice, an excellent animal model of human type 1 diabetes (2–4), long-term treatment with high doses of 1,25(OH)2 D3 reduced the incidence of diabetes by changing the cytokine balance at the local pancreatic lesion, without major side effects (5).