Risk Description . Vitamin D has previously been shown to influence midbrain dopaminergic neuron function. Forum Moderator. COMT V158M + H62H heterozygous is associated with low or high catecholamines. However, I have shifted my thoughts on this subject. But some COMT individuals may have trouble breaking these chemicals down from impaired function of the enzyme. Methylation Analysis Results Gene & Variation rsID Alleles Result COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CC -/- VDR Taq rs731236 AA +/+ VDR Fok-I not found n/a n/a MAO A R297R rs6323 T + ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 AG +/- […] Higher levels of norepinephrine. A defect will cause higher dopamine due to slower breakdown and is associated with ADD/ADHD. The V158M and H62H alleles of COMT are slowed mutations. The COMT H62H also reduces activity leading to “super COMT ++ status” in those with a V158M ++ This enzyme defect allows you to spare dopamine and nor-epinephrine, also known as the “feel good hormones”. Rawlins also believes that blood clots are more prevalent. rs4633 is a variant at codon 62 of the COMT gene, however, it does not change the amino acid sequence of the COMT protein.. It has been associated with differences in intelligence, personality, and disease risk. Because COMT is a methylation gene, it's essential to get adequate B vitamins to support COMT, especially B2, B6, B9, and B12 as well as magnesium. This can lead to irritability, hyperactivity, or abnormal behavior. The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Dec 9, 2017 - Explore Iris Robinson's board "Genetics", followed by 547 people on Pinterest. Posted 7/12/2016 2:33 PM (GMT -7) Hi and welcome! I was diagnosed with Gastroparesis this summer and have been very ill. Log in. I am heterozygous MAO-A R297R and CBS A360A. A partial defect can be useful in maintaining these important neuro-talkers within the community, particularly when bacteria are present. COMT V158M (rs4680) & Its Health Effects. V158M + H62H homozygous is associated with high catecholamines and excess estrogen. While abstract thinking, and emotion. While increasing the rate-limiting synthetic enzyme for dopamine. The reason is that these SNPs increase dopamine, noradrenalin and adrenalin in the frontal lobes of our brain. +/-COMT V158M, COMT H62H, MTRR A66G, BHMT-02, BHMT-04, AHCY-01, AHCY-02, AHCY-19; I decided to put this blog post together to summarize how each of these things specifically affects my body. The risk ‘T’ allele (in 23andme the risk allele is “A”) of rs1801181 or C1080T (also called A360A) in the CBS gene has been associated with a very mild risk of developing non-Hodgkin lymphoma 3.The risk described by the authors is mild and they are unable to describe a mechanism although an association with low dietary vitamin B6 and methionine intake was observed. Thanks in advance, Sheri Barnett I’m going to tackle the homozygous SNPs first, the ones where I have two copies of the “bad” SNP. It is crucial to address any gut issues before you thoroughly address the CBS defect. We drink tap water using a carbon filter and I am nervous about that. COMT V158M; COMT H62H; VDR Bsm; VDR Taq; ACAT1-02; MTR A2756G; MTRR A664A; CBS C699T; Addressing ACAT and SHMT SNPs ACAT1-02 (acetyl coenzyme A acetyltransferase) plays a role lipid metabolism and energy generation. My son has had sensory issues (I am told caused by suboccupital compression but he is not responding to osteopathic … The Major "C" allele is associated with: Higher risk of atherosclerosis in women . COMT V158M + H62H heterozygous is associated with low or high catecholamines. Driven to create situations that stimulate them mentally and physically, This may lead to violent, destructive or illegal behavior if left unchecked, Dr’s use antipsychotic medications to reduce a patient’s dopamine levels, Risk of developing alcohol abuse or dependence, Significantly associated with schizophrenia, Better performance tests of prefrontal cortex function and working memory, Means increased tyrosine hydroxylase expression and increased dopamine levels. rs4633. The COMT V158M or the catechol-o-methyltransferase (COMT) gene inactivates catecholamines, catechol estrogens, and catechol drugs such as L-DOPA. COMT V158M + H62H heterozygous is associated with low or high catecholamines. COMT mutations slow the activity of the COMT enzyme which slows dopamine causing dopamine excess of imbalances. Lower COMT activity. Full text here. Threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions. A 2015 study published in Sleep Medicine Reviews highlights the fact that that 30% of people are homozygous (+/+) and 50% are heterozygous (+/-) for the COMT V158M allele. You have 4 homozygous (+/+) mutations and 5 heterozygous (+/-) mutations. In the brain, COMT breaks down dopamine and norepinephrine at different rates depending on its genotype. Histamine Intollerence … People with MAO-A and COMT are some of the smartest, most-intelligent people you will ever meet. This is a thoroughly researched gene. Looking for COMT gene mutation treatments, contact us here. Which polymorphisms are we talking about? See more ideas about mthfr, mthfr mutation, mthfr gene mutation. This affects how much of these neurotransmtters are around Additionally, COMT is important in the phase II metabolism of estrogens. COMT (catechol-O-methyltransferase) helps break down certain neurotransmitters and catecholamines. These include dopamine, epinephrine, and norepinephrine. V158M + H62H homozygous is associated with high catecholamines and excess estrogen. COMT (Catechol-O-Methyltransferase) breaks down estrogen, catecholamines and neurotransmitters including dopamine, epinephrine and norepinephrine. COMT is also involved with metabolizing estrogens. Parent Gene: COMT. And if you slow something down in your body by 300% you don’t have to have a … Higher risk of endometrial cancer . Genetic Genie reports on the following polymorphisms: COMT V158M rs4680 (also called Val/Met and Met/Met) COMT H62H… as part of a 3-SNP haplotype (that includes rs4633) with incr. Joined : Sep 2006. Like L-DOPA, dopamine, epinephrine and norepinephrine. rs4680(A) = Worrier. Defects will make you more susceptible to dopamine fluctuations, therefore mood swings. Alleles (An allele is a variant form of a gene). Amazingly, the same research article also revealed that the COMT V158M polymorphism slows down the COMT system by 300%! Our Version of the Congratulations You Got Grounded Chart - to Discourage Problem Behaviors with Points, The Past Few Weeks of Overmethylation Hell, MTHFR: My Genetic Mutations, Folic Acid, and Medical Mysteries Possibly Explained. COMT -61 P199P: rs769224: A: GG-/-COMT H62H: rs4633: T: CC-/-COMT V158M: rs4680: A: GG-/-COMT (one homozygous mutation) – This gene helps break down dopamine and norepinephrine. COMTV158 is associated with a 3-4 x reduction or increase in activity and increased reaction to heat. COMT H62H rs4633 is similar in effect to rs4680. enzyme in the brain that breaks down neurotransmitters such as noradrenaline (AA allele) = Low activity or higher dopamine which needs certain nutrients for support B6, SAM, magnesium, and FAD. This article explains the basics and summarises the research. rs4680(G) = Warrior. One of the most researched variants in the human genome is a point mutation in the COMT gene called V158M (or rs4680). I just found out yesterday that I have homozygous MTHFR C677T, as well as homozygous COMT V158M, COMT H62H, VDR Taq. Individuals +/+ or +/- for these genes will degrade dopamine slowly leaving an excess of free methyl groups. The A allele results in 3 to 4-fold decrease in COMT enzyme activity [5, 6]. … While MTHFR is a key enzyme involved in serotonin, dopamine, and COMT is also important in the detoxification of xenobiotics and metabolism of catechol drugs. It can also deplete B12. The frequencies of COMT rs4680 “A” allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). COMT is also important in the detoxification of xenobiotics and metabolism of catechol drugs. I really don't … To support COMT … Enzyme Activity. As a Practioner who is homozygous COMT V158M and H62H, I swore off SAMe as a supplement. 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) is an enzyme which interacts with methionine synthase, to ensure the continued production of the essential amino acid methionine, and is encoded for by the MTRR gene 1.. Methionine is an essential amino acid and is required for numerous processes throughout the body. For questions about this blog, please contact Christina Gleason (twilightsun at gmail dot com). CBS C699T cystathionine beta synthase AKA The Hole in the Bucket. … Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels, and lower pain. COMT helps the body get rid of excess Dopamine, Epinephrine, Norepinephrine and Estrogens. The rest are heterozygous : COMT V158M COMT H62H VDR Bsm VDR Taq MTRR A66G MTR A2756G MTRR R415T BHMT-02 CBS C699T. A person who is compound heterozygous (a single C677T mutation and a single A1298C mutation, each on a different strand) will see symptoms from both defects, but the symptoms tend to be more severe. People without COMT … There are several common genetic variants that alter how the enzyme functions. Posts : 28868. A homozygous mutation of the V158M allele is associated with a 40% reduction in COMT gene activity. MTHFR activates 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). COMT degrades dopamine, norepinephrine, and many other neurotransmitter, by tacking on to them a free methyl group obtained from SAMe. This Priority # 3 Mutation Tip! Any infor you can help me with would be great! I tried to find a doctor to help me with supplementing and nutritional support, but everyone I called today seems to think I am speaking of … Those people may have trouble with methyl donors. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels and higher pain threshold. […No, I don’t have SCZ nor bipolar ] COMT catalyzes the transfer of the methyl-group from SAM to catecholamine substrates. Variations in this gene are associated with a higher risk of some neuro-physchiatirc disorders, increased sensitivity to a pain and impaired estrogen. This area of the brain is involved with personality, inhibition of behaviors, short-term memory, and planning. My daughter has not had her DNA testing done but had been diagnosed with low D and multiple sclerosis . COMT H62H rs4633 TT +/+ COMT P199P rs769224 GG -/-VDR Bsm rs1544410 CT +/-VDR Taq rs731236 AG +/-MAO-A R297R rs6323 GG -/-ACAT1-02 rs3741049 GG -/-MTHFR C677T rs1801133 AG +/-MTHFR 03 P39P rs2066470 GG -/-MTHFR A1298C rs1801131 GT +/- MTR A2756G rs1805087 AA -/-MTRR A66G rs1801394 AG +/-MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/-MTRR … In a study of 150 (Caucasian) cases of endometrial cancer, a significant increase in rs4633(T;T) genotype was observed in patients compared to controls (OR = 2.39, CI: 1.31-4.37, p = 0.004). COMT individuals can usually break down these neurotransmitters efficiently. COMTV158 is associated with a 3-4 x reduction or increase in activity and increased reaction to heat. Recently, I added in 200 mgs at dinner, and I slept well like I haven't in years. COMT +/+ = Excess Dopamine ; Excess Methyl Groups (See list below) Intolerance … COMT and Altered Neurotransmitters. A rather remarkable family… I have worked with members of this family of five — mom, dad, and three children, two adult females and an adult male — for a number of years now. MTHFR C677T homozygous . Two versions of this enzyme are made from the gene. Catechol-O-methyltransferase is important to the areas of the pre-frontal cortex. I have listed those above I case they impact the CBS gene. Researchers link COMT genetic variants to quite a variety of different diseases from mood disorders … One polymorphism, in particular, has been extensively researched in association with various mental and emotional conditions. But better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions. In this figure, we see that in post mortem prefrontal cortex tissue COMT activity in homozygous COMT V158M (listed here as met/met) as 35%-50% lower than the wild type COMT val/val. (also associated with VT risk, and schizophrenia and bipolar disorder - one of my brothers succumbed to the latter). They may also be more sensitive to pain. risk of schizophrenia and bipolar disorder. V158M + H62H homozygous is associated with high catecholamines and excess estrogen. COMT V158M and H62H heterozygous MTR A756G homozygous MAO-A (r6323) homozygous VDR VSM and Taq heterozygous MTRR A66G heterozygous. Possible estrogen imbalances and or estrogen dominance: Reduced tolerance for methyl donors such as: Because COMT can interfere with dopamine this causes imbalances such as high dopamine or low dopamine. (G allele) = High activity or lower dopamine which need inhibitors such as quercetin, green tea, and Rhodiola. I am sorry to hear that you have received results that have you concerned. A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data, On Autistic Pride Day, I Propose Actually Autistic Day, My Complex Medical Problems Too Big for smAlbany, Essential Oils for Anxiety from a Former Skeptic, Karaoke Songs for the Mezzo-Soprano Female. COMT rs165599: assoc. What Is It Like to Serve on a Grand Jury? Heterozygous or homozygous variants for the COMT V158M methionine allele slow down the COMT enzyme, affecting estrogen metabolism and the breakdown of dopamine and stress hormones.