The signaling pathway inducing NR1H3 expression in macrophages involves NF-κB dependent transcriptional gene activation and may promote anti-inflammatory effects (35). Protein localization. This publication has generated much discussion, and fortunately the possibility to validate a finding or prove it spurious can occur rapidly in genetic studies. Mouse Tissue-Resident Macrophage Markers; Stem Cell Transcription … Symbol Description Category GIFtS GC id Score; 101: RXRG: Retinoid X Receptor Gamma: Protein Coding: 41: GC01M165401: 2.70: 102: TMEFF1: Transmembrane Protein With EGF Like And Two Follistatin Like Domains 1 SDS. Of the other covariates, only sex was strongly associated with both NCEH1 and NR1H3 expression (p ≤ 0.001 and < 0.001 respectively), whereas BMI was associated with NR1H3 transcript levels alone (P = 0.035). In response to the HFD, also transcripts of Acaca, Fasn, and Cpt1 increased only or significantly more in WT, as compared with Pr2x 7 −/− mice. Product Datasheet . Results: In TCGA cohort, we found that high NR1H3 (HR=0.779, 95% CI: 0.634-0.957), NR2C1 (HR=0.673, 95% CI: 0.458-0.989) and NR2F6 (HR=0.750, 95% CI: 0.574-0.980) expressions were independent factors of favorable OS, while only low NR1H3 (log-rank test, P=0.0076) and NR2F6 (log-rank test, P=0.0395) expressions had the ability to predict poor prognosis for RFS. Gene ID 10062 Gene Symbol NR1H3 Species Human Immunogen Human recombinant protein fragment corresponding to amino acids 69-329 of human NR1H3 (NP_005684) produced in E.coli. The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene. A candidate fusion gene found in this list has a very high probability of being a false positive. 1301 - 13033 View Record in Scopus Google Scholar Tested Reactivity: Human. TaqMan® Gene Signature Arrays This array is part of a collection of TaqMan® Gene Signature Arrays that enable analysis of hundreds of TaqMan® Gene Expression Assays on a micro fluidic card with minimal effort. NR1H3 plays a central role in the transcriptional regulation of both cholesterol homeostasis and inflammation (32, 35). Programmed Cell Death. SDS. Quality is guaranteed. Western Blot: LXR alpha/NR1H3 Antibody [H00010062-D01P] - NR1H3 MaxPab rabbit polyclonal antibody. Western Blot analysis of NR1H3 expression in A-431. All; Kit; Protein; Antibody; Molecular Biology Product ; Small Molecule; Raw Material For IVD Kit; CD47｜Proteinase K｜EGFR｜BCMA｜PD-L1｜CD276｜ACE2｜TMPRSS2｜Exosome Isolation Kits. Further, TLRs have been shown to downregulate NR1H3 (35), which we also observed in PBMCs in the present … Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. COA. All. Further, in FUSCC validating cohort, we … Nuclear hormone receptors (NRs) are ligand-activated intracellular transcription factors that have profound effects on development, homeostasis and detoxification. LOADING... × Select All; Add Selected To Cart Add Selected To Array ... Entrez Gene IDs Gene Symbols RefSeq Accession numbers GenBank mRNA Accession numbers Protein IDs RNAdb IDs and Gene Symbols Array Probe IDs. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. Organelle biogenesis and maintenance. In addition, studies in mice suggest that … 21:178-180 (1993). COA. Reproduction. Trans. XX XX XX FA PU.1 XX SY B1; PU.1; Spi-1; NF-JB; NF-betaA. In the second family of ten, two people had MS and three people without MS carried the gene. Distinct gene regulatory programs define the inhibitory effects of liver X receptors, NR1H2/NR1H3 and PPARG on cancer cell proliferation. alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1. In these two families the people who developed MS had severe and rapidly progressing forms of the disease. Fusion_pair 5'Gene Junction (Chr/Position/Strand) 3'Gene Junction (Chr/Position/Strand) Breakpoint_Type Genome_Build Disease Validation PMID Gene Type Source; BIRC3_MALT1-/0/-/0/ Exonic: hg18----TICdb: ChimerPUB: Top: The fusion gene pair BIRC3--MALT1 information is available in … NAFLD grade and stage were lower in Pr2x 7 −/− than WT mice, and only 1/7 Pr2x 7 −/− RN [2]; RE0006397. Muscle contraction. Soc. Fusion gene LAF4--BCL2 is not found in the list of known false positive fusion genes. Expression. Your Good Partner in Biology Research. A novel risk score was calculated by multiplying the gene expression of each gene and its corresponding … Learn vocabulary, terms, and more with flashcards, games, and other study tools. 10062 (Human) Alternate Names. Comprehensive Genetic Test Requisition GxTM Please submit both pages of this form. alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1. 100% Guaranteed. RT Characterization of a cDNA encoding the insulin gene GAGA-binding factor, RT Pur-1 RL Biochem. Mouse Polyclonal Anti-LXR alpha/NR1H3 Antibody. The mutation was found on the gene known NR1H3, which secretes a protein known as LXRA, which can switch other genes on and off. Product Pages: Species: Gene Names: Gene Aliases: RefSeq Accessions: SNP IDs (if applicable): Mature Names (if applicable): Hs00329185_CE details, Hs00329185_CE search: Human: aci All novel discoveries must be replicated, and best efforts should be … Analysis. Product Datasheets. … Publicly available data on HCC were downloaded from the Gene Expression Omnibus (GEO) database (GSE14520/GPL3921) and TCGA, and ... CKLF, GLP1R, LHB, NR1H3, ADM, GAL, IRF5, IL18RAP, SEMA3F, PLXNA2, MMP12, ANGPT1, ECD, FABP3, LANCL1, OGFR, GH2, STC1, and OSMR) were IRGs. Start studying Lecture 5 Pt.B. Neuronal System. In cultured murine and human macrophages the synthetic LXR agonist GW3965 has been shown to reduce cytokine-induced tissue factor (TF) production [13] and we have previously shown that GW3965 dose-dependently attenuated LPS-induced release of TNF-α and prostaglandin E 2 by hepatic Kupffer … With this newly discovered mutation---which isn’t even very large; it’s simply one nucleotide being subbed in for … Related Research Areas. Gene function and disease associations were extracted from gene cards, ... (NR1H2, previously known as LXRα, and NR1H3, previously known as LXR β; Figure 1, Supplementary Table 1). Entrez Gene IDs. anti-NR1H3 Antibody reacting with Rabbit and identified with WB, ELISA. Supported Keywords: siRNA IDs Entrez Gene IDs Gene Symbols RefSeq Accession numbers GenBank mRNA … RA Kennedy G. C., Rutter W. J. RT Pur-1, a zinc finger protein that binds to purine-rich sequences, RT transactivates an insulin promoter in heterologous cells The Gene cards suite: from gene data mining to disease genome sequence analyses Curr Protoc Bioinformatics , 54 ( 2016 ) , pp. Mouse Tissue-Resident Macrophage Markers; Stem Cell Transcription … In the first family of eleven, five had MS and one without MS carried the gene. Structures. In particular, transcript expression of Srebf1 and, to a lesser extent, of Ppara, Pparg, and Nr1h3 increased in WT-HFD mice, but not or significantly less markedly in Pr2x 7 −/ −-HFD animals. gene expression in mouse macrophages [10], microglia and astrocytes [11], and human monocytes [12]. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; Validated: WB, ELISA, ICC/IF. *Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways. The identification of ten patients diagnosed with MS harboring a rare NCOA3 p.Arg485Cys substitution capable of enhancing the expression of pro-inflammatory mediators, together with a suggestive association between MS and NCOA3, and significant associations with NCOA1, NCOA5, NR1D1 and NR1H3 [6, 9], suggests an important role for nuclear receptor co-activators, and the LXR … PMID: 27401066 these data show that YXS is effective in mitigating MI/R injury by suppressing mitochondrial mediated apoptosis and oxidative stress and by upregulating LXRalpha, thereby providing a rationale for future clinical trials and clinical applications PMID: 26964694 Protein expression analysis revealed that mutant NR1H3 alters gene expression profiles, suggesting a disruption in transcriptional regulation as one of the mechanisms underlying MS pathogenesis. Some of those genes can slow or stop the inflammation that damages the myelin sheath and in some cases can actually repair damage already done by the disease. We recently published a study proposing a rare variant in the NR1H3 gene (p.R415Q, rs61731956) as responsible for the onset of multiple sclerosis (MS) in two multi-incident families. Calculations showed that for the family … Product Application Details Applications Western Blot, Immunohistochemistry Recommended Dilutions Western Blot 1:2000, Immunohistochemistry 1:150 Application Notes The observed molecular weight of the … We also assessed the relationship between the expression of our target gene set and total cholesterol levels, HDL cholesterol and LDL cholesterol in the study sample, but identified no … To this end, mice knockout for the Pr2x 7 gene (Pr2x 7 −/−) and coeval wild-type (WT) mice were fed a high-fat diet (HFD) or normal-fat diet for 16 weeks. Immune System. Metabolism of RNA. Molecules . Metabolism. Gene expression (Transcription) Hemostasis. NR1H3 (1) siRNA Type Silencer® (1) Reset Filters . Tel : 301-363-4651. In contrast, no significant effect of HFD or Pr2x 7 −/− gene deletion was observed in … Signal Transduction. A CLIA Accredited Laboratory | 4553 Winters Chapel Road #100, Atlanta, GA 30360 | 855.686.4363 | www.otogenetics.com | support@otogenetics.com Glia-activating factor is a protein that in humans is encoded by the FGF9 gene. Ligands that are … Product … RX MEDLINE; 93087555. Western Blot: LXR alpha/NR1H3 Antibody [H00010062-D01P] - Analysis of NR1H3 expression in transfected 293T cell line by NR1H3 polyclonal antibody.Lane 1: NR1H3 transfected lysate(45.70 KDa).Lane 2: Non-transfected...read more. The list has been generated from healthy human samples collected from 16 organs from Illumina BodyMap2 RNA-seq database. Gene/Protein Basic Information For NR1H3 (Source: Uniprot.org, NCBI) Uniprot Id: Q13133: NCBI Gene Id: 10062: Species Of This Entry: Human: Gene Name: NR1H3: Protein Name: Oxysterols receptor LXR-alpha: Superfamily: nuclear hormone receptor family: Alternative Names : NR1H3|alpha; Liver X receptor alpha; liver X receptor-alpha; LXR alpha; LXRA; NR1H3; Nuclear receptor subfamily 1 group H member 3; … The study identified a mutation in gene called NR1H3 in two unrelated Canadian families. Entrez Gene IDs. 10062 (Human) Alternate Names. Vesicle-mediated transport . Metabolism of proteins. Transport of small molecules. LOADING. Fibroblast … Related Research Areas. STRING interaction network for Circadian rythm related genes SuperPath Product Datasheets. Description. SARS-CoV-2: Nucleoprotein｜Spike … The fusion gene pair BIRC3--MALT1 information is available in CHIMERKB (CHIMERDB 3.0) database. Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene. Product Datasheet .